Flotillins: Signals from a Raft

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Flotillins are highly homologous proteins (known as flotillin-1 and flotillin-2, or reggie-2 and reggie-1, respectively) that localize to membrane rafts (specific cholesterol-rich microdomains in cellular membranes), and are associated with various signaling pathways, cell adhesion, membrane trafficking and axonal growth.

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What are you looking at?

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Live cell imaging allows real time measurements while maintaining the delicate balances and intricate complexity of the cell. Further, sufficient data sampling using quantitative single cell imaging addresses inaccuracies produced by averaging data from cell populations that may be heterogeneous (perhaps with subpopulations displaying opposing characteristics and behavior) and allows the exclusion of outliers. Continue reading