Towards Therapeutic Use of Antimicrobial Peptides: Conferring Cell Selectivity by Introducing Specificity Determinants

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Guest Commentary by Guangshun Wang*

We are living in an era of antibiotic resistance; fortunately, there is widespread recognition of the consequences of this dilemma. While scientists have long been fascinated by the impressive diversity of antimicrobial peptides (also called host defense peptides) that exist in bacteria, protozoa, fungi, plants, and animals, there is a current urgency to explore novel strategies to make use of these compounds as therapeutic antimicrobials. However, while these peptides can exhibit a broad spectrum of antimicrobial activity, their potential toxicity in systemic administration has represented a significant challenge for medicinal use.  Continue reading